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Can diet have an effect on Alzheimer's disease ?

Alzheimer's disease is the most common form of dementia.  It is a progressive disease in which there is a  gradual and continual death of brain cells.  Symptoms include memory loss, confusion and mood swings.

There is a connection between Alzheimer's disease and cardiovascular disease and therefore it has been suggested that known cardiovascular dietary risk factors, such as intake of saturated fat, may influence disease progression.

Epidemiological studies ( looking at groups of people and disease incidence) have identified that populations with low rates of Alzheimer's disease tended to eat more fish, monounsaturated fats and cereals.   Higher rates of the disease were found in populations with high intakes of saturated fat and  meat and who were obese.

 A recent study looking at the antioxidant resveratrol, which is found in grapes, red wine, berries and peanuts, has been shown to lower the levels of certain peptides that cause the plaques in the brain associated with Alzheimer's disease. 

Supplementation with antioxidants has not been shown to have any significant affect on the disease in trials so far, but a high intake of antioxidants through consumption of fruit and vegetables should be encouraged in those who already have the disease as well as a means of prevention.

If you would like more detailed advice please contact Emma at This email address is being protected from spam bots, you need Javascript enabled to view it   or call  01623 882853.

 

Last modified: July 2008

 Sources:

'Changing Diets, Changing Minds' Report Sustain & Mental health Foundation 2005

'Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides'   Marambaud et al, 2005 Journal of Biological Chemistry 280 (45) p37377-82

'A review of antioxidants and Alzheimer's disease'  Frank & Gupta, 2005 Annals of Clinical Psychiatry 17 (4) p269-86

'Reversing the deleterious effecst of aging on neuronal communication and behaviour: beneficial properties of fruit polyphenolic compounds'  Joseph et al, 2005 81 (1 suppl ) p313S-316S

 

 
Can food additives have an effect on behaviour ?

The idea that certain food additives can trigger adverse reactions, particularly in children, has been hotly disputed among healthcare professionals and the wider community.

The simple answer is that they can affect behaviour as well as  other physical complaints, in certain individuals.

Lets look at the evidence....

 

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What is ' leaky gut ' ?

The gut mucosa is the inner lining of the gastrointestinal tract  ( gut ) and one of its many functions is that of a barrier, keeping the stomach contents within until digestion has been fully completed.

If the gut mucosa becomes damaged, then fragments of partially digested food can leak out into the blood stream.  This is what we term ' leaky gut '.

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What are trans fatty acids ?

Unsaturated fats can exist in two different forms, as cis fats or trans fats, otherwise known as TUFA's ( trans unsaturated fatty acids ).

In nature, most of the fats found in animals and plants exist in the form of cis fats ( some trans fats are made during rumenation and so can be found in beef and butterfat ).  The cis fats found in liquid vegetable oils and fish oils can be changed in to trans fats by certain manufacturing processes, such as commercial hydrogenation.  This process stabilises the oil, preventing oxidation which causes rancidity, and as such can extend the shelf-life of many manufactured foods.

 

 

 

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What is 'sulphation deficit' ?

Sulphur-containing foods are oxidised in the body to produce sulphate by the PST (phenol-sulphur-transferase) enzyme system.

 

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