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Carnitine metabolism and autism

A genetic defect that affects the production of an enzyme involved in carnitine biosynthesis has been identified as a risk factor for a certain type of autism ( nondysmorphic).

Carnitine is made from the amino acid, lysine, and it's primary role is to combine with long-chained fatty acids (LCFAs) to form carnitine esters that can be taken into cells and be used for energy production. A deficiency of carnitine is known to have major deleterious effects on the central nervous system and treatment with L-carnitine has had some  positive results in children with both autism and ADHD ( Geier et al and Van Oudheusden & Scholte).

 For more information http://www.brainandbody.co.uk/index.php?option=com_content&task=view&id=140&Itemid=29

Source:  http://www.ncbi.nlm.nih.gov/pubmed/22566635

Posted: May 2012

References:  Geier et al, 2011 ' A prospective double-blind, randomised clinical trial of levocarnitine to treat autism spectrum disorders' Med.Sci.Monit. June 17(6) p115-123

                     Van Oudheusden and Scholte, 2002 'Efficacy of carnitine in the treatment of children with ADHD' Prostaglandins.Leukot.Essent Fatty Acids July 67(1) p33-38

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